Current Funding Announcements

See below

PRE-ANNOUNCEMENT: Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Toxic Exposures Research Program (TERP)Anticipated Funding Opportunities for FY24

PRE-ANNOUNCEMENT: Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Toxic Exposures Research Program (TERP)Anticipated Funding Opportunities for FY24

Description: The FY24 Defense Appropriations Act provides funding for the Toxic Exposures Research Program (TERP) to support high-impact toxic exposures research. This pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY24 funding opportunities. The FY24 TERP funding opportunity announcements for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the announcements are released.

Applications must address one or more of the Program Goals:

• Elucidate mechanisms of how military-related toxic exposures result in adverse effects

• Diagnose the effects of military-related toxic exposures

• Predict and prevent military-related toxic exposures

• Develop therapeutics, treatments, and strategies

Applications must address one or more Topic Areas, which include Neurotoxin Exposure and Other Military Service-Related Toxic Exposures in General (including prophylactic medications, pesticides, organophosphates, toxic industrial chemicals, materials, metals and minerals).

Pre-announcement news release: https://cdmrp.health.mil/pubs/press/2024/24terppreann

About TERP: https://cdmrp.health.mil/terp/default

Anticipated maximum funding/periods of performance

• Investigator Initiated Research Award (IIRA): $500,000/3 years

• Translational Research Award (TRA)

o $800,000/3 years

o Partnership option: $1.6M/3 years

• Clinical Trial Award (CTA)

o $1.5M/4 years

o Partnership option: $2.5M/4 years

Point of Contact: CDMRP Public Affairs, 301-619-9783, usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@health.mil

FY24 Department of Defense, Defense Health Program, Congressionally Directed Medical Research Programs (CDMRP) Joint Warfighter Medical Research Program (JWMRP) Military Medical Research and Development Award (MMRDA)

Description: Congress initiated the JWMRP in 2012 to augment and accelerate high-priority Department of Defense (DOD) and Service medical requirements and to support the logical continuation of DOD-funded research and development initiatives that are close to achieving their objectives and yielding a benefit to military medicine. Funds from the JWMRP shall not be used for new projects or for basic research. To be eligible for intramural (HT942524JWMRPMMRDA) or extramural (HT942524SJWMRPMMRDA) funding, applicants must have already received DOD core or DOD Congressional Special Interest prior year funding (including DOD Small Business Innovation SBIR/STTR awards) for the same project being proposed for continuation under this BAA. Focus Areas of interest include:

• Preventative capabilities to promote the Warfighter’s physiological and cognitive (1) performance and readiness and (2) injury prevention.

• Solutions for semi-autonomous or autonomous medical care from point of injury across the continuum of care, including support of triage, prolonged patient care, and transport in contested environments.

• Virtual/telehealth and decision support with artificial intelligence solutions to provide combat casualty care/prolonged care.

Applications/proposals must be submitted under one of the two following options:

• Military Medical Research and Development Award (MMRDA) — research does not include human subjects, human biological samples, or human data sets.

• Military Medical Research and Development Award – Clinical Research or Clinical Trial Option (MMRDA–CRTO) —research includes any human subjects, human biological samples (prospective or retrospective), or human data sets.

Find full program announcements for extramural and intramural applicants at: https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=587101

Program information: https://cdmrp.health.mil/jwmrp/default

Pre-Application (Preproposal) Deadline: 5:00 p.m. Eastern time (ET), June 3, 2024

Application Deadline: 11:59 p.m. ET, August 29, 2024

Maximum period of performance: 3 years

Maximum funding: $2 million (MMRDA) or $3.4 million (MMRDA-CRTO)

Hearing Restoration Research Program (HRRP) – FY24 Focused Research Award

Congressionally Directed Medical Research Programs (CDMRP) Hearing Restoration Research Program (HRRP) – FY24 Focused Research Award

Description: The FY24 HRRP FRA is intended to support promising research that accelerates drug discovery and therapeutic development for hearing restoration after military-relevant auditory system injury. Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the VA, and other federal government agencies are highly encouraged. To meet the intent of the award mechanism, all applications must address research in one or more of the following Focus Areas:

Improve and accelerate the translation of biological regeneration/repair mechanisms into clinical applications. Research addressing the damage, repair, and regeneration of the auditory system after military-relevant injuries is strongly encouraged.
Develop diagnostic tests that differentiate sensory, neural, synaptic, and central processing disorders, that may inform applicability and outcomes for current or future hearing restoration therapeutics.
Develop reliable in-vitro human models to facilitate the understanding, derivation, and characterization of human auditory cells, and/or to facilitate the evaluation of hearing restoration therapies.

Tinnitus or vestibular-related research is excluded.

Full award announcement: https://cdmrp.health.mil/funding/hrrp

About HRRP: https://cdmrp.health.mil/HRRP/default

Pre-Application/Submission Deadline: July 22, 2024 (5:00 p.m. Eastern)

Application Submission Deadline: August 9, 2024 (11:59 p.m. Eastern)

Maximum funding/periods of performance

Funding level 1: $250,000/2 years

Funding level 2: $750,000/3 years

Funding level 3: $1M/3 years

The CDMRP expects to allot approximately $400,000 to fund approximately one FRA – Funding Level 1 application; approximately $2.4M to fund approximately two FRA – Funding Level 2 applications; and approximately $1.6M to fund approximately one FRA – Funding Level 3 application.

Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Traumatic Brain Injury and Psychological Health Research Program (TBIHRP) Anticipated Funding Opportunities for FY24

PRE-ANNOUNCEMENT: Department of Defense Congressionally Directed Medical Research Programs (CDMRP)
Traumatic Brain Injury and Psychological Health Research Program (TBIHRP) Anticipated Funding
Opportunities for FY24
Description: The FY23 Defense Appropriations Act provides funding for TBIPHRP to support research
into the treatment, prevention, and detection of traumatic brain injury (TBI) and to improve
psychological health. This pre-announcement is to allow investigators time to plan and develop
ideas for submission to the anticipated FY23 funding opportunities. Funding opportunity
announcements, application and submission instructions will be posted on the Grants.gov website;
pre-application and application deadlines will be available when the announcements are released.
Applications must address one or more Focus Areas, not all of which will be applicable to every
award mechanism:
• Understand: research will address knowledge gaps in epidemiology, and etiology of psychological
health conditions and/or TBIs. This includes understanding of risk, protective, and biological
factors contributing to vulnerability, response, and long-term outcomes.
• Prevent and Assess: research will address the prevention, screening, diagnosis, or prognosis of
psychological health conditions and/or TBI. This includes, e.g., identification and validation of
biomarkers or other objective methods for assessment, diagnosis, prognosis, or real-time
monitoring; development of decision-making frameworks or tools that incorporate objective
assessments and may consider long-term outcomes to inform return-to-activity/duty decisions; and
development and evaluation of approaches or tools to prevent or reduce risks.
• Treat: research will address novel and repurposed inventions to improve outcomes, and efforts to
address treatment, rehabilitation, and health services. This includes interventions administered
acutely, during the post-acute phase, or during the chronic phase of injury that promote sustained
functional recovery.

Pre-announcement news release: https://cdmrp.health.mil/pubs/press/2024/24tbiphrppreann
About TBIPHRP: https://cdmrp.health.mil/tbiphrp/default

Maximum funding/periods of performance
• Clinical Trial Award
o Funding level 1: $500,000/3 years
o Funding level 2: $2M/4 years
o Funding level 3: $4M/4 years
• Focused Program Award: $5M/4 years
• Health Services Research award: $2.5M/4 years
• Translational Research Award: $1M/4 years
o Funding level 1: $500,000/3 years
o Funding level 2: $1M/4 years
• Emerging Research Award: $500,000/3 years
o Funding level 1: $700,000/3 years
o Funding level 2: $1.5M/4 years
Point of Contact: CDMRP Public Affairs, 301-619-9783, usarmy.detrick.medcom-cdmrp.mbx.cdmrp-
blic-affairs@health.mil

Maximum funding/periods of performance
• Clinical Trial Award
o Funding level 1: $500,000/3 years
o Funding level 2: $2M/4 years
o Funding level 3: $4M/4 years
• Focused Program Award: $5M/4 years
• Health Services Research award: $2.5M/4 years
• Translational Research Award: $1M/4 years
o Funding level 1: $500,000/3 years
o Funding level 2: $1M/4 years
• Emerging Research Award: $500,000/3 years
o Funding level 1: $700,000/3 years
o Funding level 2: $1.5M/4 years
Point of Contact: CDMRP Public Affairs, 301-619-9783, usarmy.detrick.medcom-cdmrp.mbx.cdmrp-
blic-affairs@health.mil

https://www.american-hearing.org/research-grants/grant-process/

(R01 Clinical Trial Not Allowed): Bioengineering Research Grants (BRG)

Description: The goal of the bioengineering research grant (BRG) program is to foster development of innovative technologies, methods, tools, models or designs that have the potential for significant impact on biomedical research by infusing principles and concepts from quantitative sciences. This opportunity encourages applications that: 1) apply a multidisciplinary approach to solve biomedical problems; and 2) develop, integrate, optimize, validate, translate or accelerate adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, and/or clinical science and practice.

Significant projects may include, but are not limited to: development, validation, and translation of promising modalities for the disease continuum, including tools for risk prediction, screening, prevention, detection, diagnosis, disease progression, intervention, monitoring treatment response, prognosis, or survival; development of quantitative, predictive models of complex biological systems; integration and optimization of technologies that significantly increase sensitivity, specificity, positive predictive value, negative predictive value, efficiency, or throughput of analysis to address unsolved biological or medical questions; in vitro and in vivo models, cell/tissue culture systems and organoids that closely mimic physiological conditions and allow mechanistic studies or engineering and testing of delivery systems, molecules/cells/tissues for therapeutic purposes, therapeutics, implants, and prosthetics that may improve treatment and healthcare.

Overall impact of these advances may include improving our understanding of molecular mechanisms, reducing disparities in access to care, promoting wellness and independent living, increasing access to and utility of technologies to improve quality of life, reducing the cost and complexity of procedures, and/or increasing throughput, sensitivity, and specificity of diagnostic tests.

NIH component participants include the National Institute on Deafness and Other Communication Disorders (NIDCD). Investigators are encouraged to contact the designated Scientific/Research contacts for individual institute focus areas that will be supported. For NIDCD, this is Nancy Freeman, Ph.D., (301) 402-3458, freemann@mail.nih.gov

Open Date (Earliest Submission Date): October 01, 2022

Expiration Date: September 08, 2025

Maximum Project Period: 5 years

Maximum Amount: Application budgets are not limited but need to reflect the actual needs of the proposed project.

Additional Information: https://grants.nih.gov/grants/guide/pa-files/PAR-22-242.html

Companion Funding Opportunity: PAR-22-243 (R01 Clinical Trial Optional) https://grants.nih.gov/grants/guide/pa-files/PAR-22-243.html

BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01 Clinical Trial Not Allowed)

RFA-NS-22-026: BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01

Clinical Trial Not Allowed)

Description: This FOA solicits applications for research projects that seek to understand how

circuit activity gives rise to mental experience and behavior using innovative, methodologically-

integrated approaches. The goal is to support adventurous projects that can realize a potentially

transformative outcome within 5 years. Applications are expected to address circuit function in the

context of specific behaviors or neural systems, such as sensation, perception, attention,

reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects

should link theory, data analysis, and/or computational approaches to experimental design and

should produce predictive models (conceptual or quantitative).

Projects should aim to improve the understanding of circuits of the central nervous system by

systematically controlling stimuli and/or behavior while actively recording and/or manipulating

dynamic patterns of neural activity. Diverse species or experimental systems and a cross-

species/comparative approach are welcome and should be chosen based on their power to address the

specific question at hand and to reveal generalizable and fundamental neuroscience principles.

Targeted BRAIN Circuit Project R01 awards will support an individual laboratory or a small

multi-PD/PI team. Projects should reflect the NIH BRAIN Initiative interests of the application of

cutting-edge methodologies to understand central nervous system circuit function and

dynamics at cellular and sub-second levels of resolution in ethologically relevant behaviors of an

organism or a well-defined neural system. Applications should offer specific, feasible, and

potentially transformative research goals as endpoints within a 5-year term

Representative topics include: Innovative approaches to understand network coding of sensory

information and/or multi-sensory integration, at multiple stages of processing, in response to

naturalistic inputs and perceptual contexts.

Letter of Intent due date(s) 30 days prior to the application due date

Application due dates: June 1, 2022; July 1, 2022; October 6, 2022; June 30, 2023; October 4,

2023; June 28, 2024; October 2, 2024

Maximum project period: 5 years

Funding amount: the BRAIN Initiative intends to commit up to an estimated total of $15 M per year

to fund 20 awards.

Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-026.html

NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

RFA-DC-22-001: NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

NIH - National Institute on Aging (NIA) and National Institute on Deafness and Other Communication

Disorders (NIDCD)

Description: This Funding Opportunity Announcement (FOA) is intended to provide an avenue for basic

scientists, clinicians and clinical scientists to jointly initiate and conduct translational

research projects which translate basic research findings into clinical tools for better human

health. The scope of this FOA includes a range of activities to encourage translation of basic

research findings which will impact the diagnosis, treatment and prevention of communication

disorders. Connection to the clinical condition must be clearly established and the outcomes of

the grant must have practical clinical impact.

Possible goals include, but are not limited to:

• Biochemical, electrophysiological and behavioral assays to enhance diagnostic capabilities.

• Pharmacology, toxicity, and pharmacokinetic for candidate therapeutics that have demonstrated

potential for the treatment of communication disorders.

• Preclinical animal research for dosage studies and toxicity when a subsequent Phase I/II

clinical trial is planned.

• Translation of new tools and techniques for better diagnostics or therapeutics, including but

not limited to, neuroprosthetic devices, drug delivery devices, neuro-electrical stimulators and

recording devices.

• Translation of laboratory-based screening tests, including biomarkers into improved ways to

identify individuals at risk for a communication disorder to allow for early intervention.

• Translation of published basic research findings into new clinical tools to better target the

treatment to the individual patient and to better predict patient response or prognosis.

• Translation of discoveries from biological, psychological, social sciences and other related

areas into innovative prevention and treatment paradigms and processes.

• Modification of laboratory measures of function or laboratory treatment protocols for use in

clinical settings.

Open Date (Earliest Submission Date): September 17, 2021

Letter of Intent Due Date(s): 30 days prior to the application due date

Application Due Date(s): October 20, 2021; June 20, 2022; February 22, 2023; October 18,

2023; June 20, 2024

Maximum Project Period: 5 years

Maximum Amount: NIDCD anticipates funding an estimated 2-3 awards in fiscal year 2022 for a total

of $1,500,000.

additional Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DC-22-001.html

Open/Active DoD Broad Agency Announcements

U.S. Military Academy Broad Agency Announcement - W911NF-20-S-0008: This BAA was released April 1, 2020, and is open until March 31, 2025. It seeks proposals for cutting- edge innovative research that could produce discoveries with significant impact to enable new and improved Army technologies and related operational capabilities in the areas of socio-cultural; information technology; ballistics, weapons and protections; energy and sustainability; materials, measurements, and facilities; unmanned systems and space; human support systems; and artificial intelligence, machine learning, and quantum technologies. The human support systems focus includes biomechanical engineering to enhance soldier readiness (human performance optimization, injury prediction/prevention, physical and cognitive augmentation, Return-to-Duty metrics, functional influence of prosthetics/exoskeletal devices) and wearable technologies and sensors to inform performance decisions (e.g., monitoring/assessment, injury prevention, recovery times).

See: Military Academy BAA

Research Interests of the Air Force Office of Scientific Research

Announcement: BAA-AFRL-AFOSR-2016-0007
Award Organization: Air Force Office of Scientific Research
Type/Mechanism: Grant
Activity Code:
Web Site: DoD: http://www.grants.gov/web/grants/view-opportunity.html?oppId=285269
Award Amount: $200,000 - $400,000 encouraged; $7.5M max

PoP: 5 years
Restrictions: None
Rolling Annual Programs: Open until Superseded
Pre-Application Due: Open until superseded
Full App Due: Open until superseded
Notes: For the sensory systems portion of the portfolio a goal is to pursue new capabilities in acoustic analysis, to enhance the intelligibility and usefulness of acoustic information. The primary approach is to discover, develop, and test principles derived from an advanced understanding of cortical and sub-cortical processes in the auditory brain. Included are efforts to model and control effects of noise interference and reverberation, understand the psychoacoustic basis of informational masking, develop new methods for automatic speech detection, classification, and identification, and enable efficient 3D spatial segregation of multiple overlapping acoustic sources.

Research

Quick Fact

#29

Hearing is the process of changing sound waves into electrical signals that the brain interprets as specific sounds.